What is Cholesterol?

“Bad cholesterol” and “Good cholesterol.”

Cholesterol is a material such as the cell membranes that make up the body, hormones that regulate the body’s function, and bile acids that help digestion and absorption.

 It is known that “LDL cholesterol” is wrapped in a container called LDL and carried to the body.

“HDL cholesterol” that is collected in a box called HDL and returned to the liver. When LDL cholesterol increases too much, it accumulates on the walls of blood vessels. It causes arteriosclerosis. so HDL cholesterol is called “good cholesterol” because it has been collected without being used up by the body.

Hypercholesterolemia occurs when cholesterol is out of balance

Cholesterol produces by the liver and is absorbed by the diet to be regulated so that it remains in the blood at a constant level.

However, if the balance lost for some reason and too much cholesterol add to the blood.

hypercholesterolemia will result. Other lifestyle disorders such as overeating and lack of exercise and other illnesses, drugs, and heredity, can cause this.

Too much LDL cholesterol leads to arteriosclerosis

Too much LDL cholesterol can build up on the walls of blood vessels, creating plaques. It is hard to notice because there is no subjective symptom, but if this condition is justify unchecked, the arteries will become narrower and harder, and “arteriosclerosis” will progress. When plaque broke, and blood clots (thrombus) forme.

it may cause serious illness such as myocardial infarction or cerebral infarction.

LDL cholesterol levels associate with the incidence of myocardial infarction and angina

Studies of countries worldwide have reported that higher LDL cholesterol levels lead to more cases of myocardial infarction and angina, resulting in higher mortality. It has clarified that the LDL cholesterol level increases in Japanese, and the number of incidents causing myocardial infarction and angina increases.

Child health checkup for lifestyle-related

 diseases-early detection of familial hypercholesterolemia in Kagawa prefecture 

 Familial hypercholesterolemia (FH) is a hereditary disease in which LDL cholesterol levels, which say to be wrong, are naturally high. Early detection is difficult, and only some are receiving treatment. Under such circumstances, in Kagawa prefecture. we are working on medical examinations to prevent lifestyle-relate diseases in children at “All Kagawa”. 

Conducted preventive health checkups for childhood lifestyle-related diseases targeting fourth-grade elementary school students through regional collaboration

For primary school 4th grade

 In Japan, it estimates that one in 200 to 500 people have FH. The current situation is that early diagnosis and treatment are tricky because they overlook due to miserable subjective symptoms.

 According to Professor Tetsuo Minamino of the Department of Cardiology.

Kagawa University Hospital. the risk of developing coronary artery disease is approximately 13 times higher if no gene inherite from one of the parents. “It says that arteriosclerosis saw in FH from around ten years old. And if diagnosis and treatment stare at that stage, improvement in the post-treatment course could expect.”

 In Kagawa prefecture, which has many patients with diabetes and has the highest consultation rate in the USA.

to prevent lifestyle-related diseases and heart diseases cause by them. we have been conducting health checkups to avoid lifestyle-relate diseases since 2012. 

A blood test conduct in 4th graders in 17 municipalities in the prefecture to examine glucose metabolism.which is abnormal in diabetes, and lipids, and liver functions.

 Useful for finding illness of parents 

 For children under 15 years of age.

LH cholesterol level of 140 mg/dL or higher and FH or early coronary artery disease in the family (within 2nd degree) (myocardial infarction and angina occurring in males under 55 years old.

females under 65 years past) diagnosed with FH. For children whose LDL cholesterol level exceeds the standard in the childhood lifestyle disease prevention medical examination.

we recommend that the school visit a nearby medical institution, and if there is a possibility of FH.

four hospitals such as Kagawa University Hospital Diagnose at, and treat in cooperation with the local family doctor.

 About 8,000 children undergo this medical examination annually. about 300 children have LDL cholesterol levels of 140 mg/dL or higher. Of these, 20 to 30 are FH. Professor Minamino and colleagues have added genetic Super p Force tests in collaboration with Kanazawa University and Osaka University since April 2018. As a result, the accuracy improves, and about 80 people, including the parents, diagnose with FH annually.

 Professor Minamino said, “It is rare for prefectures to carry out preventive health checkups for childhood lifestyle-related diseases globally. Efforts to prevent arteriosclerosis in children and myocardial infarction and angina in parents spread worldwide. I expect that.” (Medical Tribune = Current Affairs)

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